The ride to Cades Cove is nice but, beware if someone sees a Bear you may be sitting in traffic for 20 or 30 minutes. The next couple of weeks is the ideal time to go, especially if UT is having a game that Saturday theres less traffic and the leaves are changing.
The Cherohala Skyway, Robbinsville, Dragon and Foothills Parkway loop is worth spending a Saturday on. It will take you about 5 hours or so, and that includes stopping at some of the biker destinations. From Knoxville the whole ride was about 180 miles. If you want do this ride and you are not a local, stay in West Knoxville. From there you can choose to go in the Cherohala by driving to Sweet Water via interstate or highway 411 to highway 68. there isnt a gas station for about 40 miles on the Cherehola, I reccomend you top off at Wegiels in Sweet Water, they have 100%.
Mark 16:15King James Version (KJV)
15 And he said unto them, Go ye into all the world, and preach the gospel to every creature.